The Reverend Thomas Carraher came to Angola in 1874 as pastor and purchased a lot on the corner of Transit and Brant-Angola Roads for a parish cemetery. Previously all Catholic funerals from Angola went to Dunkirk for Burial. The first burial in Holy Cross Cemetery was for the deceased, Dennis Graeney, March 7, 1879.

Following Father Carraher, the pastorate at Angola had many changes in the next few years. The Reverend Arthur Barlow was appointed in 1878, the Reverend Christopher O'Byrne in 1881, the Reverend George Burns also in 1881, and the Reverend J.P. Grant in 1884.

The Reverend Richard T. Burke succeeded Father McCarthy in 1902. Seeing the need for a parish hall, Father Burke had a basement dug beneath the church. He also bought additional property for the parish cemetery. Holy Cross Cemetery was dedicated October 21, 1904.

When Father Lalley became pastor, the parish numbered 700 members; the church seated 300; and 2500 to 3000 summer residents took part in the Mass celebrated at the City Pavilion every Sunday. Seeing the need for better accommodations for the thousands of summer vacationers of the Catholic faith, Father Lalley approached Bishop Duffy about the possibility of erecting a chapel on the Old Lake Shore Road. The plan was approved at a meeting in the chancery and in 1938 reached fruition. The new structure was named St. Peter's Chapel.

As the successor to Father Lalley, the Reverend Thomas E. Fernan came to Angola in February, 1949. During the next ten years the parish enjoyed a period of growth, improvements, and innovations. It saw the acquisition in 1949 of a convent to house eight nuns, the redecorating of the church, the refurnishing of the sanctuary, the installation of a new organ, and the most formidable of all projects, the acquisition of land on Prospect Street in 1951 and the building of the school on part of it. The doors of the school opened for classes September 9, 1953.

In 1960, Father Shea acquired property on Prospect Street inward from Lake Street for a proposed driveway. Ground was broken for a new church and rectory July 30, 1961. The completion of the church was celebrated with its first Mass on June 21, 1962, and its dedication by Bishop Leo Smith on September 9, 1962.

Fr. Shea retired in 1981 as Pastor of Most Precious Blood but remained as Pastor Emeritus until his death June 24, 1995.  Fr. J. Grant Higgins was pastor from 1982 until 1998.  His assistants were Rev. Charles Zadora and Rev. John Hajduk.  The lake property, on which St. Peter’s Chapel stood, was sold and the chapel razed.  The statue of Our Lady of the Lake, which had been donated by Dr.& Mrs. Walter King in the early 1950s, was removed from the chapel and relocated to the church grounds.
 

Rev. Bernard U. Nowak became pastor in 1998 and brought about many physical improvements to the church such as renovating the sanctuary, construction of a baptismal pool, refurbishing the church ceiling, and carpeting.  He also replaced the roofing and boilers at several structures, including the school.   After purchasing a new organ and sound system for the church, he began planning for the construction of a chapel adjacent to the church.  The chapel was completed in 2004.  In addition to its use as a place of worship for daily Masses, the chapel serves as a meeting room for parish groups.

A major change to the parish occurred when the Diocese of Buffalo announced that Most Precious Blood School was one of the 13 Catholic schools to close in June 2007 as part of the diocesan restructuring process.  Fr. Matt implemented many changes in the Faith Formation Program to accommodate the youth no longer being served by the school and a  Youth Ministry was developed for high school children.